One hundred chronic, withdrawn, akinetic, psychotic patients were given iproniazid in hopes of making them more accessible to group interaction and more manageable. We did not find the drug helpful in those patients whose affect was characterized by apathy and flatness. On the other hand, the drug appeared to be definitely useful in one-half of those cases where the primary symptom was depression. Serious side effects may result from the drug and dosage must be very carefully adjusted for each patient.Abstract Teaser