Psychodynamic observations made during the mescaline-induced state in 124 patients are reviewed. Mescaline produces a "state of being" in which the clinical spectrum can range from sleep to rage and from normalcy to thoroughly disorganized mental states. Anxiety is considered the background upon which the mescaline experience evolves. One may consider the mescaline-induced state under three headings: 1. Hostility-aggression, 2. Sexuality, and 3. The transference. Various recurring symbolic gestures were noted, and many were frequently of a sexual nature.The primary role of anxiety is reviewed and some theoretical concepts presented. Much further work remains to be done.Abstract Teaser