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The American Journal of Psychiatry, VOL. 114, No. 4

Article | October 01, 1957

THE ANTIDOTAL ACTION OF SODIUM SUCCINATE IN THE MESCALINE PSYCHOSIS

IAN STEVENSON; ANDREW J. SANCHEZ

Am J Psychiatry 1957;114:328-332.

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Department of Psychiatry and Neurolology, School of Medicine, University of Virginia, Charlottesville, Va.

Department of Psychiatry and Neurolology, Louisiana State University School of Medicine, New Orleans, La.

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Abstract

1. Sodium succinate was found to have a definite antidotal effect on the mescaline psychosis in each of 12 subjects.2. The effect varied greatly in different subjects. Moreover, the effect was rather transient and there was little shortening of the total duration of mescaline effect.3. The most plausible hypothesis of the succinate effect is that succinate provides a substrate for oxidation in the brain tissues when the oxidation of other substrates, e.g., glucose, lactate and pyruvate has been depressed by the mescaline.

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