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The American Journal of Psychiatry, VOL. 113, No. 11

Article | May 01, 1957

AN EVALUATION OF PROMAZINE HYDROCHLORIDE IN PSYCHIATRIC PRACTICE

STANLEY LESSE

Am J Psychiatry 1957;113:984-987.

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The Neurological Institute of the Presbyterian Hospital of New York and the College of Physicians and Surgeons, Columbia University, New York, N. Y.

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Abstract

1. Fifty psychiatric patients treated with promazine hydrochloride, a new phenothiazine derivative, are reviewed.2. The drug was effective in one-third of the patients treated, but only in those who demonstrated marked anxiety.3. Dosages and methods of administration are considered.4. Adverse side-effects are mild and relatively uncommon as compared with those produced by chlorpromazine.5. Promazine appears to be as effective as chlorpromazine as a tranquillizer in psychiatric practice and deserves further study.

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