1. A case of Cushing's Syndrome in a 23-year old male is presented.2. Proper diagnosis was delayed by an overwhelming psychotic picture, resembling schizophrenia.3. Initial treatment consisting of a 2-stage roentgen irradiation of the pituitary region was rendered, producing no significant mental improvement.4. Final treatment consisting of complete adrenalectomy, performed in 2 stages and followed by replacement therapy, resulted in complete remission of all physical and mental symptoms and signs within 6 months, following the first stage of adrenalectomy.Abstract Teaser