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The American Journal of Psychiatry, VOL. 111, No. 12

Article | June 01, 1955

EXPERIMENTAL PSYCHIATRY II Clinical and Physio-Chemical Observations in Experimental Psychosis

MAX RINKEL; ROBERT W. HYDE; HARRY C. SOLOMON; HUDSON HOAGLAND

Am J Psychiatry 1955;111:881-895.

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The Department of Psychiatry, Harvard Medical School, and the Boston Psychopathic Hospital

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Abstract

1. Experimental psychiatry, i.e., the comprehensive study of experimentally produced psychosis, is important for the advancement of psychiatry.2. The diethylamide of d-lysergic acid (LSD) has proven an excellent tool for investigation of experimentally produced psychotic-like manifestations.3. Clinical, psychological, physiological, and biochemical evidence is offered which indicates that the adrenalin System is involved in the LSD-produced emotional and psychotic phenomena.4. Theoretical reflections concerning the enzymatic adrenalin system as the basis of the development of schizophrenia and other psychoses are reported.

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