1. Methamphetamine hydrochloride, a sympathomimetic drug and a central stimulant, is described as a facilitating agent and adjuvant to psychotherapy.2. The brief literature is reviewed and the physiological and psychological effects are described, both immediate and remote.3. Sixty-six patients were treated with Methedrine in office practice, and the results were beneficial in selected cases.4. Complications were encountered rarely; they consist of headache and the risk of precipitating an acute psychotic reaction.5. The clinical results are ascribed to the stimulating properties of methamphetamine; the effect is an increase of ego strength and self-esteem, together with the stripping away of superficial ego defenses and the partial dissolution of the resistances.Abstract Teaser