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The American Journal of Psychiatry, VOL. 108, No. 8

Article | February 01, 1952

EFFECTS OF MESCALINE AND LYSERGIC ACID (d-LSD-25)

PAUL H. HOCH; JAMES P. CATTELL; HARRY H. PENNES

Am J Psychiatry 1952;108:579-584.

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The Department of Research Psychiatry, N. Y. State Psychiatric Institute, New York City; Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York City.

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Abstract

The effects of mescaline and lysergic acid were studied in schizophrenic patients. It was found that physiological changes were produced in these patients and that their mental symptomatology was markedly aggravated. The observations made with the above-mentioned drugs on normal individuals were compared with those seen in schizophrenic patients. Mescaline and lysergic acid are drugs that disorganize the psychic integration of a person. This disorganization is much more apparent in schizophrenics than in normals. The diagnostic, prognostic, and therapeutic use of these drugs is also discussed.

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