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American Journal of Psychiatry

Volume 179, Issue 11

November 2022

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Editor’s Note

November 2022

Polygenic Risk Scores and Genetics in Psychiatry

Ned H. Kalin, M.D.

Pages:781–784
Published Online:1 November 2022

https://doi.org/10.1176/appi.ajp.20220789

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Editorials

November 2022

From Soldier’s Heart to Shared Genetic Risk: PTSD and Cardiovascular Disease

Robert J. Ursano, M.D., and
Murray B. Stein, M.D., M.P.H.

Pages:785–787
Published Online:1 November 2022

https://doi.org/10.1176/appi.ajp.20220778

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November 2022

Harnessing the Power of Population Cohorts to Study the Relationship Between Endocrine-Metabolic Disorders and Depression

Anders Jespersen, Ph.D.,
Zeynep Yilmaz, Ph.D.,
Bjarni J. Vilhjálmsson, Ph.D.

Pages:788–790
Published Online:1 November 2022

https://doi.org/10.1176/appi.ajp.20220798

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November 2022

A Revolution Is Brewing in How We Understand the Shared Genetic Causes of Psychiatric Disorders

Angelica Ronald, Ph.D., and
Oliver Pain, Ph.D.

Pages:791–793
Published Online:1 November 2022

https://doi.org/10.1176/appi.ajp.20220777

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November 2022

Proof-of-Principle Study on ECT Illustrates Challenges and Possible Merits of Using Polygenic Risk Scores to Predict Treatment Response in Psychiatry

Bart P.F. Rutten, M.D., Ph.D., and
Suzanne C. van Bronswijk, M.D., Ph.D.

Pages:794–797
Published Online:1 November 2022

https://doi.org/10.1176/appi.ajp.20220783

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November 2022

Early-Onset Psychosis and Autism Spectrum Disorder: Similar Rates of Deleterious Copy Number Variants, Yet Diverse Phenotypic Manifestations

David H. Skuse, M.D., F.R.C.Psych.

Pages:798–799
Published Online:1 November 2022

https://doi.org/10.1176/appi.ajp.20220790

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Reviews and Overviews

November 2022

Polygenic Scores in Psychiatry: On the Road From Discovery to Implementation

Cathryn M. Lewis, Ph.D.,
Evangelos Vassos, M.D., Ph.D.

Pages:800–806
Published Online:1 November 2022

https://doi.org/10.1176/appi.ajp.20220795

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CME

November 2022

Defining Recovery From Alcohol Use Disorder: Development of an NIAAA Research Definition

Brett T. Hagman, Ph.D.,
Daniel Falk, Ph.D.,
Raye Litten, Ph.D.,
George F. Koob, Ph.D.

Pages:807–813
Published Online:12 April 2022

https://doi.org/10.1176/appi.ajp.21090963

Abstract
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The objective of this article is to provide an operational definition of recovery from alcohol use disorder (AUD) to facilitate the consistency of research on recovery and stimulate further research. The construct of recovery has been difficult to ...

Articles

CMEAudio

November 2022

Leveraging Large-Scale Genetics of PTSD and Cardiovascular Disease to Demonstrate Robust Shared Risk and Improve Risk Prediction Accuracy

Antonia V. Seligowski, Ph.D.,
Burook Misganaw, Ph.D.,
Lucie A. Duffy, B.A.,
Kerry J. Ressler, M.D., Ph.D.,
Guia Guffanti, Ph.D.

Pages:814–823
Published Online:7 September 2022

https://doi.org/10.1176/appi.ajp.21111113

Abstract
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Objective:Individuals with posttraumatic stress disorder (PTSD) are significantly more likely to be diagnosed with cardiovascular disease (CVD) (e.g., myocardial infarction, stroke). The evidence for this link is so compelling that the National Institutes ...

November 2022

Genetic and Environmental Contribution to the Co-Occurrence of Endocrine-Metabolic Disorders and Depression: A Nationwide Swedish Study of Siblings

Marica Leone, Ph.D.,
Ralf Kuja-Halkola, Ph.D.,
Amy Leval, Ph.D.,
Agnieszka Butwicka, M.D., Ph.D.,
Jakob Skov, M.D., Ph.D.,
Ruyue Zhang, Ph.D.,
Shengxin Liu, M.Sc.,
Henrik Larsson, Ph.D.,
Sarah E. Bergen, Ph.D.

Pages:824–832
Published Online:21 September 2022

https://doi.org/10.1176/appi.ajp.21090954

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Objective:Depression is common in individuals with endocrine-metabolic disorders and vice versa, and a better understanding of the underlying factors contributing to the comorbidity of these disorders is needed. This study investigated the familial ...

November 2022

Charting the Landscape of Genetic Overlap Between Mental Disorders and Related Traits Beyond Genetic Correlation

Guy Hindley, M.D.,
Oleksandr Frei, Ph.D.,
Alexey A. Shadrin, Ph.D.,
Weiqiu Cheng, Ph.D.,
Kevin S. O’Connell, Ph.D.,
Romain Icick, M.D.,
Nadine Parker, Ph.D.,
Shahram Bahrami, Ph.D.,
Naz Karadag, M.Sc.,
Daniel Roelfs, M.Sc.,
Børge Holen, M.D.,
Aihua Lin, Ph.D.,
Chun C. Fan, M.D.,
Srdjan Djurovic, Ph.D.,
Anders M. Dale, Ph.D.,
Olav B. Smeland, M.D.,
Ole A. Andreassen, M.D.

Pages:833–843
Published Online:7 September 2022

https://doi.org/10.1176/appi.ajp.21101051

Abstract
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Objective:Mental disorders are heritable and polygenic, and genome-wide genetic correlations (r_g) have indicated widespread shared genetic risk across multiple disorders and related traits, mirroring their overlapping clinical characteristics. However, r_g ...

CME

November 2022

Association Between Polygenic Risk Scores and Outcome of ECT

Robert Sigström, M.D., Ph.D.,
Kaarina Kowalec, Ph.D.,
Lina Jonsson, Ph.D.,
Caitlin C. Clements, Ph.D.,
Robert Karlsson, Ph.D.,
Axel Nordenskjöld, M.D., Ph.D.,
Erik Pålsson, Ph.D.,
Patrick F. Sullivan, M.D.,
Mikael Landén, M.D., Ph.D.

Pages:844–852
Published Online:7 September 2022

https://doi.org/10.1176/appi.ajp.22010045

Abstract
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Objective:Identifying biomarkers associated with response to electroconvulsive therapy (ECT) may aid clinical decisions. The authors examined whether greater polygenic liabilities for major depressive disorder, bipolar disorder, and schizophrenia are ...

Video

November 2022

Similar Rates of Deleterious Copy Number Variants in Early-Onset Psychosis and Autism Spectrum Disorder

Catherine A. Brownstein, Ph.D.,
Elise Douard, M.Sc.,
Josephine Mollon, Ph.D.,
Richard Smith, Ph.D.,
Margaret A. Hojlo, B.A.,
Ananth Das, B.A.,
Maria Goldman, B.A.,
Emily Garvey, B.A.,
Kristin Cabral, B.S.,
Jianqiao Li, B.S.,
Joshua Bowen, B.S.,
Abhijit S. Rao, B.S.A.,
Casie Genetti, M.S., C.G.C.,
Devon Carroll, A.P.R.N.-B.C.,
Emma E. M. Knowles, Ph.D.,
Emma Deaso, B.A.,
Pankaj B. Agrawal, M.D.,
Alan H. Beggs, Ph.D.,
Eugene D’Angelo, Ph.D.,
Laura Almasy, Ph.D.,
Aaron Alexander-Bloch, M.D., Ph.D.,
Zohra Saci, Ph.D.,
Clara A. Moreau, Ph.D.,
Guillaume Huguet, Ph.D.,
Anthony J. Deo, M.D., Ph.D.,
Sébastien Jacquemont, M.D.,
David C. Glahn, Ph.D.,
Joseph Gonzalez-Heydrich, M.D.

Pages:853–861
Published Online:24 August 2022

https://doi.org/10.1176/appi.ajp.21111175

Abstract
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Objective:Copy number variants (CNVs) are strongly associated with neurodevelopmental and psychotic disorders. Early-onset psychosis (EOP), where symptoms appear before 18 years of age, is thought to be more strongly influenced by genetic factors than ...

Letters to the Editor

November 2022

Cannabis and Cannabinoids in Psychiatry: Risks and Benefits

H. Yavuz Ince, M.D.

Page:862
Published Online:1 November 2022

https://doi.org/10.1176/appi.ajp.20220233

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November 2022

Distinguishing the Effects of Lead-Time Bias and Duration of Untreated Psychosis

Katherine G. Jonas, Ph.D.,
Laura J. Fochtmann, M.D.,
Greg Perlman, Ph.D.,
John M. Kane, M.D.,
Evelyn J. Bromet, Ph.D.,
Roman Kotov, Ph.D.

Pages:862–863
Published Online:1 November 2022

https://doi.org/10.1176/appi.ajp.20220384

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November 2022

Distinguishing the Effects of Lead-Time Bias and Duration of Untreated Psychosis: Reply to Jonas et al.

Donal O’Keeffe, Ph.D.,
Anthony Kinsella, M.Sc.,
John L. Waddington, Ph.D., D.Sc.,
Mary Clarke, M.D.

Pages:863–864
Published Online:1 November 2022

https://doi.org/10.1176/appi.ajp.20220384r

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APA Official Actions

November 2022

APA Council Reports

Pages:865–880
Published Online:1 November 2022

https://doi.org/10.1176/appi.ajp.22179009

First Page
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Other Items of Interest

November 2022

Correction to Hagman et al.

Page:813
Published Online:1 November 2022

https://doi.org/10.1176/appi.ajp.21090963correction

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