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American Journal of Psychiatry

Volume 171, Issue 12

December 2014

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In This Issue

December 2014

Page:A24
Published Online:1 December 2014

https://doi.org/10.1176/appi.ajp.2014.17112issue

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Editorials

December 2014

From Bench to Bedlam

Roy H. Perlis, M.D.

Pages:1233–1235
Published Online:1 December 2014

https://doi.org/10.1176/appi.ajp.2014.14091198

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December 2014

Neurobehavioral Aspects of Multidimensional Psychopathology

William G. Iacono, Ph.D.

Pages:1236–1239
Published Online:1 December 2014

https://doi.org/10.1176/appi.ajp.2014.14091132

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December 2014

¹³C Magnetic Resonance Spectroscopy and Glutamate Metabolism in Mood Disorders: Current Challenges, Potential Opportunities

David J. Bond, M.D., Ph.D.
Kelvin O. Lim, M.D.

Pages:1240–1242
Published Online:1 December 2014

https://doi.org/10.1176/appi.ajp.2014.14091155

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December 2014

Robert Freedman, M.D.
David A. Lewis, M.D.
Robert Michels, M.D.
Daniel S. Pine, M.D.
Susan K. Schultz, M.D.
Carol A. Tamminga, M.D.
Misty Richards, M.D., M.S.

Pages:1243–1247
Published Online:1 December 2014

https://doi.org/10.1176/appi.ajp.2014.14091156

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Commentary

December 2014

DSM Issues: Incorporation of Biological Tests, Avoidance of Reification, and an Approach to the “Box Canyon Problem”

Kenneth S. Kendler, M.D.

Pages:1248–1250
Published Online:1 December 2014

https://doi.org/10.1176/appi.ajp.2014.14081018

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Introspection

December 2014

Expanding the Envelope

Benjamin Brody, M.D.

Pages:1251–1252
Published Online:1 December 2014

https://doi.org/10.1176/appi.ajp.2014.14070883

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Clinical Case Conference

December 2014

Mercury Poisoning: A Case of a Complex Neuropsychiatric Illness

Xuebing Huang, M.D.
Samuel Law, M.D., F.R.C.P.C.
Dan Li, M.D.
Xin Yu, M.D.
Bing Li, M.D.

Pages:1253–1256
Published Online:1 December 2014

https://doi.org/10.1176/appi.ajp.2013.12101266

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Images in Psychiatry

December 2014

Daniel P. Mason, M.D.

Pages:1257–1258
Published Online:1 December 2014

https://doi.org/10.1176/appi.ajp.2014.14091149

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Reviews and Overviews

December 2014

Toward a Biosignature for Suicide

Maria A. Oquendo, M.D.
Gregory M. Sullivan, M.D.
Katherin Sudol, B.A.
Enrique Baca-Garcia, M.D., Ph.D.
Barbara H. Stanley, Ph.D.
M. Elizabeth Sublette, M.D., Ph.D.
J. John Mann, M.D.

Pages:1259–1277
Published Online:31 October 2014

https://doi.org/10.1176/appi.ajp.2014.14020194

Abstract
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Objective:Suicide, a major cause of death worldwide, has distinct biological underpinnings. The authors review and synthesize the research literature on biomarkers of suicide, with the aim of using the findings of these studies to develop a coherent model ...

Articles

December 2014

An Inflammatory Biomarker as a Differential Predictor of Outcome of Depression Treatment With Escitalopram and Nortriptyline

Rudolf Uher, M.D., Ph.D.
Katherine E. Tansey, Ph.D.
Tracy Dew, B.Sc.
Wolfgang Maier, M.D.
Ole Mors, M.D., Ph.D.
Joanna Hauser, Ph.D.
Mojca Zvezdana Dernovsek, M.D.
Neven Henigsberg, M.D.
Daniel Souery, M.D., Ph.D.
Anne Farmer, M.D., F.R.C.Psych.
Peter McGuffin, Ph.D., F.R.C.P.

Pages:1278–1286
Published Online:31 October 2014

https://doi.org/10.1176/appi.ajp.2014.14010094

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Objective:Major depressive disorder has been linked with inflammatory processes, but it is unclear whether individual differences in levels of inflammatory biomarkers could help match patients to treatments that are most likely to be beneficial. The ...

December 2014

Identification and Replication of a Combined Epigenetic and Genetic Biomarker Predicting Suicide and Suicidal Behaviors

Jerry Guintivano, Ph.D.
Tori Brown
Alison Newcomer, M.Sc.
Marcus Jones
Olivia Cox, B.Sc.
Brion S. Maher, Ph.D.
William W. Eaton, Ph.D.
Jennifer L. Payne, M.D.
Holly C. Wilcox, Ph.D.
Zachary A. Kaminsky, Ph.D.

Pages:1287–1296
Published Online:31 October 2014

https://doi.org/10.1176/appi.ajp.2014.14010008

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Considerable research suggests that suicide involves effects of genes, the environment, and their interaction. Analysis of three independent data sets of post-mortem brains revealed signs of increased methylation in one particular gene, SKA2, a finding ...

December 2014

Clinical Outcomes and Genome-Wide Association for a Brain Methylation Site in an Antidepressant Pharmacogenetics Study in Mexican Americans

Ma-Li Wong, M.D.
Chuanhui Dong, M.D., Ph.D.
Deborah L. Flores, M.D.
Monika Ehrhart-Bornstein, Ph.D.
Stefan Bornstein, M.D., Ph.D.
Mauricio Arcos-Burgos, M.D., Ph.D.
Julio Licinio, M.D.

Pages:1297–1309
Published Online:31 October 2014

https://doi.org/10.1176/appi.ajp.2014.12091165

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Objective:The authors compared the effectiveness of fluoxetine and desipramine treatment in a prospective double-blind pharmacogenetics study in first-generation Mexican Americans and examined the role of whole-exome functional gene variations in the ...

December 2014

Neural and Cognitive Correlates of the Common and Specific Variance Across Externalizing Problems in Young Adolescence

Natalie Castellanos-Ryan, Ph.D.
Maren Struve, Ph.D.
Robert Whelan, Ph.D.
Tobias Banaschewski, M.D., Ph.D.
Gareth J. Barker, Ph.D.
Arun L.W. Bokde, Ph.D.
Uli Bromberg, Dipl.Psych.
Christian Büchel, M.D.
Herta Flor, Ph.D.
Mira Fauth-Bühler, Ph.D.
Vincent Frouin, Ph.D.
Juergen Gallinat, M.D.
Penny Gowland, Ph.D.
Andreas Heinz, Ph.D.
Claire Lawrence, Ph.D.
Jean-Luc Martinot, M.D., Ph.D.
Frauke Nees, Ph.D.
Tomas Paus, M.D., Ph.D.
Zdenka Pausova, M.D.
Marcella Rietschel, M.D.
Trevor W. Robbins, Ph.D.
Michael N. Smolka, M.D.
Gunter Schumann, M.D., Ph.D.
Hugh Garavan, Ph.D.
Patricia J. Conrod, Ph.D.
The IMAGEN Consortium

Pages:1310–1319
Published Online:31 October 2014

https://doi.org/10.1176/appi.ajp.2014.13111499

Abstract
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Longitudinal and family-based research suggests that conduct disorder, substance misuse, and ADHD involve both unique forms of dysfunction as well as more specific dysfunctions unique to each condition. Using direct measures of brain function, this study ...

December 2014

Glutamate Metabolism in Major Depressive Disorder

Chadi G. Abdallah, M.D.
Lihong Jiang, Ph.D.
Henk M. De Feyter, Ph.D.
Madonna Fasula, A.P.R.N.
John H. Krystal, M.D.
Douglas L. Rothman, Ph.D.
Graeme F. Mason, Ph.D.
Gerard Sanacora, M.D., Ph.D.

Pages:1320–1327
Published Online:31 October 2014

https://doi.org/10.1176/appi.ajp.2014.14010067

Abstract
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Research on novel treatments for major depressive disorder focuses quite deeply on glutamate function, and this research would benefit from a brain-imaging technique that precisely quantified glutamate function. Signs of a specific form of glutamate-...

December 2014

Effects of Depression, Anxiety, Comorbidity, and Antidepressants on Resting-State Heart Rate and Its Variability: An ELSA-Brasil Cohort Baseline Study

Andrew H. Kemp, Ph.D.
Andre R. Brunoni, M.D., Ph.D.
Itamar S. Santos, M.D., Ph.D.
Maria A. Nunes, M.D., Ph.D.
Eduardo M. Dantas, Ph.D.
Roberta Carvalho de Figueiredo, Ph.D.
Alexandre C. Pereira, M.D., Ph.D.
Antonio L.P. Ribeiro, M.D., Ph.D.
José G. Mill, M.D., Ph.D.
Rodrigo V. Andreão, Ph.D.
Julian F. Thayer, Ph.D.
Isabela M. Benseñor, M.D., Ph.D.
Paulo A. Lotufo, M.D., Dr.P.H.

Pages:1328–1334
Published Online:31 October 2014

https://doi.org/10.1176/appi.ajp.2014.13121605

Abstract
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Objective:Increases in resting-state heart rate and decreases in its variability are associated with substantial morbidity and mortality, yet contradictory findings have been reported for the effects of the mood and anxiety disorders and of ...

Letters to the Editor

December 2014

Brief Versus Intensive Psychosocial Treatments for Bipolar Disorder: Time for Stepped Care?

Sagar V. Parikh, M.D., F.R.C.P.C.

Page:1335
Published Online:1 December 2014

https://doi.org/10.1176/appi.ajp.2014.14070887

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December 2014

Response to Parikh

David J. Miklowitz, Ph.D.
Christopher D. Schneck, M.D.
Boris Birmaher, M.D.
Melissa P. Delbello, M.D.
David A. Axelson, M.D.

Pages:1335–1336
Published Online:1 December 2014

https://doi.org/10.1176/appi.ajp.2014.14070887r

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December 2014

Psychotherapy and Psychiatric Science

Raoul Belzeaux, M.D., Ph.D.
Michel Cermolacce, M.D., Ph.D.
Jean Naudin, M.D., Ph.D.

Pages:1336–1337
Published Online:1 December 2014

https://doi.org/10.1176/appi.ajp.2014.14060725

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December 2014

Ventromedial Syndrome With Normal Cognitive Functioning in Vascular Depression

Kevin J. Manning, Ph.D.
Faith M. Gunning, Ph.D.
Amanda R. McGovern, Ph.D.
Nabil Kotbi, M.D.
George S. Alexopoulos, M.D.

Pages:1337–1338
Published Online:1 December 2014

https://doi.org/10.1176/appi.ajp.2014.14050595

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Correction

December 2014

Page:1338
Published Online:1 December 2014

https://doi.org/10.1176/appi.ajp.2014.17112correction

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Book Forum

December 2014

Race, Memory and the Apartheid Archive: Towards a Transformative Psychosocial Praxis

Carol A. Bernstein, M.D.

Pages:1339–1340
Published Online:1 December 2014

https://doi.org/10.1176/appi.ajp.2014.14040428

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December 2014

Doing Psychoanalysis in Tehran

Salman Akhtar, M.D.

Page:1340
Published Online:1 December 2014

https://doi.org/10.1176/appi.ajp.2014.14040521

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December 2014

Remnants of a Life on Paper: A Mother and Daughter’s Struggle with Borderline Personality Disorder

Frank Yeomans, M.D., Ph.D.

Pages:1341–1342
Published Online:1 December 2014

https://doi.org/10.1176/appi.ajp.2014.14070881

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December 2014

Under the Red Roof: One Hundred Years at Northern State Hospital

Taylor Black, M.D.

Page:1342
Published Online:1 December 2014

https://doi.org/10.1176/appi.ajp.2014.14010038

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In Appreciation

December 2014

Reviewers for The American Journal of Psychiatry

Pages:1343–1348
Published Online:1 December 2014

https://doi.org/10.1176/appi.ajp.2014.17112reviewers

First Page
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