Dr. Luchins and Colleagues Reply
To the Editor: We agree with Ronald Pies, M.D., that the optimal daily dose of risperidone must be individualized and hope our finding that 5.7 mg was the average daily dose of risperidone in patients who continued taking medication does not confuse this issue. It is unfortunate that the original finding by Marder and Meibach (1)—that, on average, 6 mg was the more effective daily dose than 2, 10, or 16 mg—has been interpreted to mean that 6 mg is an optimal dose for all.
1. Marder SR, Meibach RC: Risperidone in the treatment of schizophrenia. Am J Psychiatry 1994; 151:825–835Link, Google Scholar