Pharmacokinetic Determinants of the Response to Single Doses of Chlordiazepoxide
Abstract
Blood concentrations of the minor tranquilizer chlordiazepoxide were measured in nine healthy volunteers after administration of single 25-mg. doses. Peak blood concentrations and rates of absorption and disappearance varied considerably among the subjects. Such pharmacokinetic variations have important clinical consequences and probably contribute to individual differences in the response to minor tranquilizers.
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